The narrative of Pico's School is driven by a small yet unforgettable cast of characters, each embodying distinct archetypes and contributing to the game's anarchic charm. These characters are not merely pixels on a screen; they are central to the game's controversy, its humor, and its enduring legacy. Their interactions, motivations, and ultimate fates weave together a story that, despite its brevity, has resonated with millions. At the heart of Pico's School is Pico, the titular protagonist and accidental hero. When the school descends into chaos, initiated by Cassandra's shocking outburst, Pico, initially portrayed as an ordinary student happily learning about apples and bananas in class, finds himself thrust into a survival situation. He blacks out during the initial massacre, only to awaken and discover his classmates brutally killed. From this horrific starting point, Pico transforms from a seemingly innocent schoolkid into a gun-wielding vigilante, determined to put an end to the violence. Pico's evolution from a typical student to a hardened fighter is one of the game's most striking elements. He is depicted as "upright" in his initial appearance, yet quickly adapts to the brutal reality of his situation, acquiring an assault rifle and confronting the goth kids responsible for the carnage. This shift highlights a darker, more aggressive and homicidal side that, according to later interpretations and appearances, becomes a defining aspect of his character, particularly in the context of subsequent Flash animations and games, including his role in Friday Night Funkin'. In these later iterations, Pico is often portrayed with untreated schizophrenia and homicidal tendencies, leading him to be constantly armed out of a fear of being attacked. This depth, whether initially intended or retroactively applied, adds a layer of tragic complexity to his otherwise heroic journey within Pico's School. Pico's signature orange hair, green attire, and a propensity for automatic weapons like MAC-10s, Uzis, or M16 assault rifles have made him instantly recognizable. His determination to confront the Goth Punks and ultimately Cassandra showcases a strong sense of justice, even if delivered through extreme measures. He is a character forged in fire, a symbol of resistance against overwhelming odds, and a testament to the raw, unfiltered creative freedom that defined early Newgrounds. His popularity is such that he transcended Pico's School to become the de facto mascot for the entire Newgrounds platform, appearing in over a hundred Flash movies and games. No hero is complete without a compelling villain, and in Pico's School, Cassandra fills this role with unsettling effectiveness. She is the catalyst for the game's horrific events, a goth-punk classmate who interrupts a mundane lesson with a scathing denunciation of the educational system, labeling it "bullshit," before opening fire on her teacher and fellow students. Her nihilistic worldview and abrupt, violent actions immediately establish the game's dark tone. Cassandra's initial appearance is that of a stereotypical goth kid, with dark clothing and sharp, upward-pointing red hair. However, as Pico confronts her and her followers, a shocking revelation unfolds: Cassandra is not merely a disgruntled teenager but an alien, specifically a member of an alien race called "Phenilians." This twist elevates the conflict from a disturbing school shooting to a broader, almost cosmic battle, adding an unexpected layer of science fiction to the narrative. Her transformation into a bizarre monster with telekinetic powers during the final boss battle further solidifies her otherworldly nature. Cassandra represents the destructive force Pico must overcome. Her motivations are rooted in a disdain for conventional society and an alien agenda, making her a formidable and somewhat enigmatic antagonist. While her initial actions are shocking and brutal, the underlying alien manipulation adds a layer of detachment, allowing the player to view her not just as a human perpetrator but as an instrument of a larger, sinister plan. In the alternate retelling, Pico's School: Love Conquers All, her character is re-contextualized, suggesting a possibility for peace and acceptance, even greeting Pico and Nene. This highlights the character's malleability and the community's willingness to explore different facets of her persona. Nene (pronounced "nay-nay") is one of Pico's friends and a significant character in the broader Pico franchise, even starring in her own preceding game, Nene Interactive Suicide. In Pico's School, Nene is found in the hallway, visibly distressed and praying amidst the chaos. She begs Pico to end her life, unable to cope with the "blood and violence" and her anxiety triggered by the school shooting. This moment presents the player with a grim choice: either kill Nene out of mercy or spare her. Canonically, Nene survives the massacre, demonstrating her resilience despite her profound emotional distress. Nene's character is marked by her suicidal tendencies and, as per her character profile, signs of promiscuity and an addiction to sharp melee weapons. Her struggles with anxiety, which Tom Fulp himself noted allows players to project their own anxieties onto her, provide a poignant contrast to Pico's aggressive resolve. Despite her vulnerabilities, Nene remains a key member of Pico's core trio, alongside Darnell, and her presence adds a layer of emotional depth to the otherwise action-oriented game. She represents the innocent victims of the school's tragedy, and her survival, even if fraught with inner turmoil, offers a glimmer of hope amidst the darkness. Darnell is the third member of Pico's core trio, a character also introduced in the Pico franchise prior to Pico's School in Darnell's Pyro 101. While his direct role in the events of Pico's School is less prominent than Pico's or Cassandra's, Darnell is an integral part of the broader Pico universe. He is characterized as a pyromaniac with a "supergenius intellect," often involved in misadventures with Pico and Nene. In Pico's School, Darnell doesn't actively participate in the fight against the Goth Punks. His presence is more implied through his connection to the broader narrative and his status as one of Pico's closest friends. His unique personality—a blend of intelligence and destructive tendencies—makes him a memorable, if briefly seen, character. The original concept for the unreleased Pico 2 would have seen Pico explore the city, eventually leading him to Darnell's house, hinting at a more significant role for Darnell in the planned sequel. His inclusion in the "Pico School Trio" alongside Pico and Nene underscores his importance as one of the original and most iconic companions in the franchise.