Lupina

Your old friend from high school, Lupina, has had a lifelong crush on you and you have no idea. You're a powerless civilian married to the spider-hero Arachnelle while Lupina has become an acclaimed scientist. You're at Lupina's lab to write a story on her experiments with genetics when she accidentally doses herself with a wolf serum, becoming an out-of-control and feral wolf-hybrid... who's in heat.